{"id":4175,"date":"2025-10-07T12:21:37","date_gmt":"2025-10-07T03:21:37","guid":{"rendered":"https:\/\/www.doochang.co.kr\/blog\/%ec%97%90%ec%9d%b4%eb%b9%84%ec%97%98%eb%b0%94%ec%9d%b4%ec%98%a4-4-1bb-%eb%8b%a8%ec%9d%bc%ed%95%ad%ec%b2%b4-%ea%b5%ad%eb%82%b4-%ed%8a%b9%ed%97%88-%ed%9a%8d%eb%93%9d%ec%9c%bc%eb%a1%9c-%ed%95%ad%ec%95%94\/"},"modified":"2025-10-07T12:21:37","modified_gmt":"2025-10-07T03:21:37","slug":"%ec%97%90%ec%9d%b4%eb%b9%84%ec%97%98%eb%b0%94%ec%9d%b4%ec%98%a4-4-1bb-%eb%8b%a8%ec%9d%bc%ed%95%ad%ec%b2%b4-%ea%b5%ad%eb%82%b4-%ed%8a%b9%ed%97%88-%ed%9a%8d%eb%93%9d%ec%9c%bc%eb%a1%9c-%ed%95%ad%ec%95%94","status":"publish","type":"post","link":"https:\/\/www.doochang.co.kr\/blog\/%ec%97%90%ec%9d%b4%eb%b9%84%ec%97%98%eb%b0%94%ec%9d%b4%ec%98%a4-4-1bb-%eb%8b%a8%ec%9d%bc%ed%95%ad%ec%b2%b4-%ea%b5%ad%eb%82%b4-%ed%8a%b9%ed%97%88-%ed%9a%8d%eb%93%9d%ec%9c%bc%eb%a1%9c-%ed%95%ad%ec%95%94\/","title":{"rendered":"\uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624 4-1BB \ub2e8\uc77c\ud56d\uccb4 \uad6d\ub0b4 \ud2b9\ud5c8 \ud68d\ub4dd\uc73c\ub85c \ud56d\uc554 \uc5f0\uad6c \uac00\uc18d\ud654"},"content":{"rendered":"<p>\uc774\uc911\ud56d\uccb4 \uc804\ubb38\uae30\uc5c5 \uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624\uac00 4-1BB \ub2e8\uc77c\ud56d\uccb4\uc640 \uadf8 \ud65c\uc6a9 \ubc29\ubc95\uc5d0 \ub300\ud55c \uad6d\ub0b4 \ud2b9\ud5c8\ub97c \ud655\ubcf4\ud588\ub2e4\uace0 26\uc77c \ubc1c\ud45c\ud588\ub2e4. \uc774\ubc88 \ud2b9\ud5c8\ub294 2019\ub144 12\uc6d4\uc5d0 \uad6d\uc81c \ucd9c\uc6d0\ub41c \ud6c4, 2039\ub144\uae4c\uc9c0\uc758 \uad8c\ub9ac\ub97c \ubcf4\uc7a5\ubc1b\uac8c \ub418\uc5c8\ub2e4. \uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624\ub294 \uc774\ubbf8 \ubbf8\uad6d, \uc911\uad6d, \uc77c\ubcf8, \ud638\uc8fc\uc5d0\uc11c \ud574\ub2f9 \ud2b9\ud5c8\ub97c \ub4f1\ub85d \uc644\ub8cc\ud588\uc73c\uba70, \uc720\ub7fd\uc5d0\uc11c\ub294 \uc2ec\uc0ac\uac00 \uc9c4\ud589 \uc911\uc774\ub2e4.<\/p>\n<p>4-1BB\ub294 \uba74\uc5ed \uc2dc\uc2a4\ud15c\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 T \uc138\ud3ec\uc758 \ud65c\uc131\ud654\uc5d0 \uad00\uc5ec\ud558\ub294 \ub2e8\ubc31\uc9c8\ub85c, \uc774 \ub2e8\ubc31\uc9c8\uacfc \uacb0\ud569\ud558\ub294 4-1BB \ub2e8\uc77c\ud56d\uccb4\ub294 T \uc138\ud3ec\ub97c \ud65c\uc131\ud654\ud558\uc5ec \uc554 \uc138\ud3ec\ub97c \uacf5\uaca9\ud558\ub3c4\ub85d \uc720\ub3c4\ud558\ub294 \uae30\uc804\uc744 \uac00\uc9c0\uace0 \uc788\ub2e4. \uc774 \uae30\uc220\uc740 \ucc98\uc74c\uc73c\ub85c \ube0c\ub9ac\uc2a4\ud1a8 \ub9c8\uc774\uc5b4\uc2a4 \uc2a4\ud045(Bristol Myers Squibb\u00b7BMS)\uc5d0 \uc758\ud574 \uac1c\ubc1c\ub418\uc5c8\uc73c\uba70, \uc784\uc0c1\uc5d0\uc11c \ub6f0\uc5b4\ub09c \ud56d\uc554 \ud6a8\ub2a5\uc744 \ubcf4\uc600\uc73c\ub098, \uc2ec\uac01\ud55c \uac04 \ub3c5\uc131 \ubb38\uc81c\ub85c \uc778\ud574 \uac1c\ubc1c\uc774 \uc911\ub2e8\ub410\ub2e4.<\/p>\n<p>\uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624\ub294 \uc774\ub7ec\ud55c \ud55c\uacc4\ub97c \uadf9\ubcf5\ud558\uae30 \uc704\ud574 \uc774\uc911\ud56d\uccb4 \uad6c\uc870\uc758 &#8216;\uadf8\ub7a9\ubc14\ub514-T(Grabody-T)&#8217;\ub97c \uac1c\ubc1c\ud588\ub2e4. \uc774\uc911\ud56d\uccb4\ub294 \ud074\ub77c\uc6b0\ub51818.2(Claudin18.2) \ubc0f HER2 \uac19\uc740 \uc554 \ud56d\uc6d0\uacfc \uacb0\ud569\ud55c \ud6c4, \ud2b9\uc815 \uc885\uc591 \ubbf8\uc138\ud658\uacbd\uc5d0\uc11c\ub9cc T \uc138\ud3ec\uac00 \ud65c\uc131\ud654\ub418\ub3c4\ub85d \uc124\uacc4\ud560 \uc218 \uc788\uc5b4, \ubcf4\ub2e4 \ud6a8\uacfc\uc801\uc778 \ud56d\uc554 \uce58\ub8cc\uac00 \uac00\ub2a5\ud558\ub2e4. \ud604\uc7ac \uc784\uc0c1 \ub2e8\uacc4\uc5d0 \uc788\ub294 \uadf8\ub7a9\ubc14\ub514-T \uae30\ubc18\uc758 \uc774\uc911\ud56d\uccb4\uc5d0\ub294 ABL111(\uc9c0\ubc14\uc2a4\ud1a0\ubbf9\u00b7Givastomig), ABL503(\ub77c\uc9c0\uc2a4\ud1a0\ubbf9\u00b7Ragistomig), ABL103, ABL104(YH32364), ABL105(YH32367) \ub4f1\uc774 \ud3ec\ud568\ub418\uc5b4 \uc788\ub2e4.<\/p>\n<p>\ud2b9\ud788 ABL111(\uc9c0\ubc14\uc2a4\ud1a0\ubbf9)\uc740 \ubbf8\uad6d\uc5d0\uc11c \ub2c8\ubcfc\ub8e8\ub9d9(Nivolumab) \ubc0f \ud654\ud559\uce58\ub8cc\uc81c\uc640\uc758 \ubcd1\uc6a9 \uc694\ubc95\uc5d0 \ub300\ud55c \uc784\uc0c1 1b\uc0c1\uc744 \uc9c4\ud589 \uc911\uc774\uba70, \uc62c\ud574 7\uc6d4\uc5d0\ub294 \uc6a9\ub7c9 \uc99d\ub7c9(Dose Escalation) \ud30c\ud2b8\uc5d0\uc11c \uae0d\uc815\uc801\uc778 \ub370\uc774\ud130\ub97c \ubc1c\ud45c\ud588\ub2e4. \ub0b4\ub144 1\ubd84\uae30\uc5d0\ub294 \uc784\uc0c1 1b\uc0c1 \uc6a9\ub7c9 \ud655\uc7a5(Dose Expansion) \ud30c\ud2b8\uc758 \ud0d1\ub77c\uc778(top-line) \ub370\uc774\ud130\ub3c4 \uacf5\uac1c\ub420 \uc608\uc815\uc774\ub2e4. \ub610\ud55c ABL103\uc740 \ubbf8\uad6d, \ud55c\uad6d, \ud638\uc8fc\uc5d0\uc11c \ud3a8\ube0c\ub864\ub9ac\uc8fc\ub9d9(Pembrolizumab) \ubc0f \ud0c1\uc13c(Taxane)\uacfc\uc758 \uc0bc\uc911 \ubcd1\uc6a9\uc694\ubc95\uc5d0 \ub300\ud55c \uc784\uc0c1 1b\/2\uc0c1\uc744 \uc9c4\ud589\ud558\uace0 \uc788\uc73c\uba70, ABL503(\ub77c\uc9c0\uc2a4\ud1a0\ubbf9)\uc740 \ubbf8\uad6d\uacfc \ud55c\uad6d\uc5d0\uc11c \ub2e8\ub3c5\uc694\ubc95\uc5d0 \ub300\ud55c \uc784\uc0c1 1\uc0c1\uc744 \uc9c4\ud589 \uc911\uc774\ub2e4.<\/p>\n<p>\uc774\uc0c1\ud6c8 \uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624 \ub300\ud45c\ub294 &#8220;4-1BB \uae30\ubc18 \uc774\uc911\ud56d\uccb4\ub4e4\uc758 \uae00\ub85c\ubc8c \uc784\uc0c1\uc774 \uc21c\uc870\ub86d\uac8c \uc9c4\ud589\ub418\uace0 \uc788\ub2e4&#8221;\uba70, &#8220;\ucd5c\uadfc\uc5d0\ub294 \uae30\uc874 \uce58\ub8cc\uc81c\uc640\uc758 \ubcd1\uc6a9\uc744 \ud1b5\ud574 \ud56d\uc554 \ud6a8\ub2a5\uc744 \uadf9\ub300\ud654\ud560 \uc218 \uc788\ub294 \uc784\uc0c1 \uc804\ub7b5\uc744 \uc218\ub9bd\ud558\uace0 \uc788\uc73c\uba70, \ud574\uc678 \ud2b9\ud5c8 \ud655\ubcf4\ub3c4 \uc801\uadf9\uc801\uc73c\ub85c \ucd94\uc9c4\ud558\uace0 \uc788\ub2e4&#8221;\uace0 \ubc1d\ud614\ub2e4. \uadf8\ub294 \uc774\uc5b4, &#8220;ABL111(\uc9c0\ubc14\uc2a4\ud1a0\ubbf9)\uc774 \uc784\uc0c1 1b\uc0c1\uc5d0\uc11c \uae0d\uc815\uc801\uc778 \ub370\uc774\ud130\ub97c \ubcf4\uc778 \ub9cc\ud07c, \uadf8\ub7a9\ubc14\ub514-T \ud50c\ub7ab\ud3fc\uc758 \uac00\uce58\ub3c4 \ud568\uaed8 \uc0c1\uc2b9\ud560 \uac83\uc73c\ub85c \uae30\ub300\ud55c\ub2e4&#8221;\uace0 \ub367\ubd99\uc600\ub2e4. \uc774\ub7ec\ud55c \uc5f0\uad6c\uc640 \uac1c\ubc1c\uc774 \uc9c0\uc18d\ub41c\ub2e4\uba74, \uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624\ub294 \ud56d\uc554 \uce58\ub8cc\uc758 \uc0c8\ub85c\uc6b4 \uc9c0\ud3c9\uc744 \uc5ec\ub294 \ub370 \uae30\uc5ec\ud560 \uac83\uc73c\ub85c \uc804\ub9dd\ub41c\ub2e4.<\/p>\n<p>[\uad00\ub828\uae30\uc0ac] <a href = 'https:\/\/n.news.naver.com\/mnews\/article\/277\/0005658167?sid=101' >https:\/\/n.news.naver.com\/mnews\/article\/277\/0005658167?sid=101<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uc774\uc911\ud56d\uccb4 \uc804\ubb38\uae30\uc5c5 \uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624\uac00 4-1BB \ub2e8\uc77c\ud56d\uccb4\uc640 \uadf8 \ud65c\uc6a9 \ubc29\ubc95\uc5d0 \ub300\ud55c \uad6d\ub0b4 \ud2b9\ud5c8\ub97c \ud655\ubcf4\ud588\ub2e4\uace0 26\uc77c \ubc1c\ud45c\ud588\ub2e4. \uc774\ubc88 \ud2b9\ud5c8\ub294 2019\ub144 12\uc6d4\uc5d0 \uad6d\uc81c \ucd9c\uc6d0\ub41c \ud6c4, 2039\ub144\uae4c\uc9c0\uc758 \uad8c\ub9ac\ub97c \ubcf4\uc7a5\ubc1b\uac8c \ub418\uc5c8\ub2e4. \uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624\ub294 \uc774\ubbf8 \ubbf8\uad6d, \uc911\uad6d, \uc77c\ubcf8, \ud638\uc8fc\uc5d0\uc11c \ud574\ub2f9 \ud2b9\ud5c8\ub97c \ub4f1\ub85d \uc644\ub8cc\ud588\uc73c\uba70, \uc720\ub7fd\uc5d0\uc11c\ub294 \uc2ec\uc0ac\uac00 \uc9c4\ud589 \uc911\uc774\ub2e4. 4-1BB\ub294 \uba74\uc5ed \uc2dc\uc2a4\ud15c\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 T \uc138\ud3ec\uc758 \ud65c\uc131\ud654\uc5d0 \uad00\uc5ec\ud558\ub294 \ub2e8\ubc31\uc9c8\ub85c, \uc774 \ub2e8\ubc31\uc9c8\uacfc \uacb0\ud569\ud558\ub294 4-1BB \ub2e8\uc77c\ud56d\uccb4\ub294 [&hellip;]<\/p>\n","protected":false},"author":77,"featured_media":67,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_yoast_wpseo_focuskw":"\uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624","_yoast_wpseo_metadesc":"\uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624\uac00 4-1BB \ub2e8\uc77c\ud56d\uccb4\uc640 \uadf8 \ud65c\uc6a9\uc5d0 \ub300\ud55c \uad6d\ub0b4 \ud2b9\ud5c8\ub97c \ud655\ubcf4\ud588\ub2e4. \uc774 \ud2b9\ud5c8\ub294 2039\ub144\uae4c\uc9c0\uc758 \uad8c\ub9ac\ub97c \ubcf4\uc7a5\ud558\uba70, \uc774\ubbf8 \ubbf8\uad6d, \uc911\uad6d, \uc77c\ubcf8, \ud638\uc8fc\uc5d0\uc11c\ub3c4 \ub4f1\ub85d \uc644\ub8cc\ub418\uc5c8\ub2e4. \uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624\ub294 \uc774\uc911\ud56d\uccb4 \uad6c\uc870\uc758 '\uadf8\ub7a9\ubc14\ub514-T'\ub97c \uac1c\ubc1c\ud558\uc5ec T \uc138\ud3ec\ub97c \ud65c\uc131\ud654\ud574 \uc554 \uc138\ud3ec\ub97c \uacf5\uaca9\ud558\ub294 \uae30\uc804\uc744 \uad6c\ud604\ud558\uace0 \uc788\uc73c\uba70, \ud604\uc7ac \uc5ec\ub7ec \uc784\uc0c1 \uc2dc\ud5d8\uc744 \uc9c4\ud589 \uc911\uc774\ub2e4.","footnotes":""},"categories":[2],"tags":[4261,1068,4260,4262,4264],"class_list":["post-4175","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-2","tag-4-1bb","tag-fta","tag-4260","tag-4262","tag-4264"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624 4-1BB \ub2e8\uc77c\ud56d\uccb4 \uad6d\ub0b4 \ud2b9\ud5c8 \ud68d\ub4dd\uc73c\ub85c \ud56d\uc554 \uc5f0\uad6c \uac00\uc18d\ud654 - \ub450\ucc3d\ud2b9\ud5c8\ubc95\ub960\uc0ac\ubb34\uc18c<\/title>\n<meta name=\"description\" content=\"\uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624\uac00 4-1BB \ub2e8\uc77c\ud56d\uccb4\uc640 \uadf8 \ud65c\uc6a9\uc5d0 \ub300\ud55c \uad6d\ub0b4 \ud2b9\ud5c8\ub97c \ud655\ubcf4\ud588\ub2e4. \uc774 \ud2b9\ud5c8\ub294 2039\ub144\uae4c\uc9c0\uc758 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property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624 4-1BB \ub2e8\uc77c\ud56d\uccb4 \uad6d\ub0b4 \ud2b9\ud5c8 \ud68d\ub4dd\uc73c\ub85c \ud56d\uc554 \uc5f0\uad6c \uac00\uc18d\ud654 - \ub450\ucc3d\ud2b9\ud5c8\ubc95\ub960\uc0ac\ubb34\uc18c\" \/>\n<meta property=\"og:description\" content=\"\uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624\uac00 4-1BB \ub2e8\uc77c\ud56d\uccb4\uc640 \uadf8 \ud65c\uc6a9\uc5d0 \ub300\ud55c \uad6d\ub0b4 \ud2b9\ud5c8\ub97c \ud655\ubcf4\ud588\ub2e4. \uc774 \ud2b9\ud5c8\ub294 2039\ub144\uae4c\uc9c0\uc758 \uad8c\ub9ac\ub97c \ubcf4\uc7a5\ud558\uba70, \uc774\ubbf8 \ubbf8\uad6d, \uc911\uad6d, \uc77c\ubcf8, \ud638\uc8fc\uc5d0\uc11c\ub3c4 \ub4f1\ub85d \uc644\ub8cc\ub418\uc5c8\ub2e4. \uc5d0\uc774\ube44\uc5d8\ubc14\uc774\uc624\ub294 \uc774\uc911\ud56d\uccb4 \uad6c\uc870\uc758 &#039;\uadf8\ub7a9\ubc14\ub514-T&#039;\ub97c \uac1c\ubc1c\ud558\uc5ec T \uc138\ud3ec\ub97c \ud65c\uc131\ud654\ud574 \uc554 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